Reaktion #40368

ord-6d605ae120b142b89b2218dc15bdf324

Reaktionsgleichung

O.O=C1COc2ccc(OCc3ccccc3)cc2N1.O=CC=O
(6-benzyloxy-4H-benzo[1,4]oxazin-3-one)-glyoxal hydrate
CC(C)(N)Cc1ccc(O)cc1
1,1-dimethyl-2-(4-hydroxyphenyl)ethylamine
Cl
hydrochloride
→
CC(C)(Cc1ccc(O)cc1)NCC(O)c1cc(OCc2ccccc2)cc2c1OCC(=O)N2
title compound
CC(C)(Cc1ccc(O)cc1)NCC(O)c1cc(OCc2ccccc2)cc2c1OCC(=O)N2
8-{2-[1,1-dimethyl-2-(4-hydroxyphenyl)ethylamino]-1-hydroxyethyl}-6-benzyloxy-4H-benzo[1,4]oxazin-3-one

Edukte

O.O=C1COc2ccc(OCc3ccccc3)cc2N1.O=CC=O
(6-benzyloxy-4H-benzo[1,4]oxazin-3-one)-glyoxal hydrate
CC(C)(N)Cc1ccc(O)cc1
1,1-dimethyl-2-(4-hydroxyphenyl)ethylamine
Cl
hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound is prepared from 10 g of (6-benzyloxy-4H-benzo[1,4]oxazin-3-one)-glyoxal hydrate and 4.6 g of 1,1-dimethyl-2-(4-hydroxyphenyl)ethylamine analogously to the method for Example 3(a). Yield: 9.0 g (64%, hydrochloride); melting point: 255° C.-258° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727984B2uspto-grants-2010_06