Reaktion #40364

Reaktionsgleichung

4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline

acetonitrile

N-(dimethoxymethyl)-N-methylethanamine

→

N′-{4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylimido-formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe reaction mixture was refluxed for 20 hrs
3. 3
   EinengenThe reaction mixture was concentrated in vacuo
4. 4
   workup.ADDITIONdiluted with ethyl acetate
5. 5
   Waschenwashed with water
6. 6
   TrocknenThe organic layer was dried over magnesium sulfate
7. 7
   Einengenconcentrated in vacuo
8. 8
   Sonstigeyielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45

Vorschrift

To a mixture of 310 mg (0.8 mmol) of 4-[(2-chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethyl-aniline in 20 ml acetonitrile 208 mg (1.5 mmol) of N-(dimethoxymethyl)-N-methylethanamine (77% pure) was added. The reaction mixture was refluxed for 20 hrs. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate and concentrated in vacuo yielded 220 mg (59%) with a purity of 72% log P (pH=2.3)=1.45.

Quelle