Reaktion #40362

Reaktionsgleichung

4-[2-(3-chloro-2-methyl-phenoxy)-pyrimidin-4-yloxy]-2,5-dimethyl-phenylamine

methanol

N-(dimethoxymethyl)-N-methyl-ethanamine

→

N′-{4-[2-(3-chloro-2-methyl-phenoxy)-pyrimidin-4-yloxy]-2,5-dimethyl-phenyl}-N-ethyl-N-methyl-formamidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TrocknenThe reaction mixture was dried over magnesium sulfate
3. 3
   Einengenconcentrated in vacuo
4. 4
   Sonstigeyielded 290 mg (76%) with a purity of 78%

Vorschrift

To a mixture of 293 mg (0.7 mmol) of 4-[2-(3-chloro-2-methyl-phenoxy)-pyrimidin-4-yloxy]-2,5-dimethyl-phenylamine in 20 ml methanol 182 mg (1.05 mmol) of N-(dimethoxymethyl)-N-methyl-ethanamine (77% pure) was added. The reaction mixture was stirred for 20 hrs at 45° C. The reaction mixture was dried over magnesium sulfate concentrated in vacuo and yielded 290 mg (76%) with a purity of 78%; log P (pH 2.3)=2.08.

Quelle