Reaktion #40338

ord-036640b60e664529845661e0ac98e940

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC(=O)C(Br)C1
3-bromo-4-oxo-piperidine-1-carboxylic acid tert-butyl ester
NC(=S)N=C(N)N
2-imino-4-thiobiuret
→
CC(C)(C)OC(=O)N1CCc2nc(NC(=N)N)sc2C1
title compound
CC(C)(C)OC(=O)N1CCc2nc(NC(=N)N)sc2C1
2-guanidino-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)N1CCC(=O)C(Br)C1
3-bromo-4-oxo-piperidine-1-carboxylic acid tert-butyl ester
NC(=S)N=C(N)N
2-imino-4-thiobiuret

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Analogously to the preparation of Example C-01, 3-bromo-4-oxo-piperidine-1-carboxylic acid tert-butyl ester is reacted with 2-imino-4-thiobiuret to form the title compound. tR 2.55 min (LC-1); ESI-MS (+): m/z 298.25 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727979B2uspto-grants-2010_06