Reaktion #4027

Reaktionsgleichung

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe solution was heated for 15 hours
2. 2
   Temperaturunder reflux
3. 3
   Extraktionthe organic layer was extracted with chloroform
4. 4
   WaschenAfter washing the
5. 5
   Extraktionextract three times with water
6. 6
   Sonstigethe chloroform was removed by distillation
7. 7
   SonstigeThe residue was recrystallized from a mixture of acetone and hexane

Vorschrift

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

Quelle