Reaktion #4017

Reaktionsgleichung

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

Ausbeute 91.3%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe resulting solution was washed with 3N HCl (10 ml)
2. 2
   SonstigeThe organic portion was evaporated
3. 3
   Sonstigethe residue chromatographed over silica gel

Vorschrift

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

Quelle