Reaktion #4014

Reaktionsgleichung

ethacrolein

diethyl 3-chloro-2-oxo-butanedioate

ammonium sulfamate

→

title product

Ausbeute 86.0%

diethyl 5-ethylpyridine-2,3-dicarboxylate

Ausbeute 86.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   Temperaturat reflux
3. 3
   Sonstigethe solvent removed by distillation under reduced pressure
4. 4
   workup.ADDITIONThe residue is treated with water
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   SonstigeThe organic phase is separated
7. 7
   Einengenconcentrated in vacuo
8. 8
   Sonstigethe residue purified by column chromatography on silica gel using 4:1 hexane-ethyl acetate as the eluent

Vorschrift

A stirred mixture of ethacrolein, (4.2 g, 0.05 mol), diethyl 3-chloro-2-oxo-butanedioate, (11.2 g, 0.05 mol) and ammonium sulfamate, (15.4 g, 0.135 mol) in ethanol (37 mL) is heated at reflux. After 15 hours the mixture is cooled to room temperature and the solvent removed by distillation under reduced pressure. The residue is treated with water and extracted with ethyl acetate. The organic phase is separated and concentrated in vacuo and the residue purified by column chromatography on silica gel using 4:1 hexane-ethyl acetate as the eluent to give 10.8 g (75% yield) of the title product as an oil which is shown to be 95% pure by a gas chromatography assay.

Quelle