Reaktion #3982

Reaktionsgleichung

Water

1-Chloromethylnaphthalene

4-benzoylureidopiperidine

triethylamine

→

1-Benzoyl-3-[1-(naphth-1-ylmethyl)piperid-4-yl]urea

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitated solid filtered off
2. 2
   FiltrationThe title compound was filtered off
3. 3
   Trocknendried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.

Vorschrift

1-Chloromethylnaphthalene (0.88 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.

Quelle