Reaktion #3966

Reaktionsgleichung

potassium hydroxide

8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine

→

8-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxy-purine

Lösungsmittel

benzyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Filtrationfiltered
3. 3
   workup.ADDITIONthe filtrate is mixed with ether
4. 4
   Sonstigethe precipitate obtained
5. 5
   Sonstigeis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)]

Vorschrift

An amount of 4.5 gm of powdered potassium hydroxide is dissolved in 70 ml of benzyl alcohol, and then 7.2 gm of 8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine are added. The mixture is heated to 150° C. for three hours, cooled, and filtered, the filtrate is mixed with ether, and the precipitate obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)].

Quelle