Reaktion #3950

Reaktionsgleichung

2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

hydrochloric acid

→

2-(2-Dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionneutralized, and extracted with ethyl acetate
2. 2
   WaschenAfter washing with water
3. 3
   Trocknendrying with magnesium sulfate
4. 4
   Sonstigethe ethyl acetate phase is evaporated
5. 5
   SonstigeThe residue is crystallized by trituration in ether/petroleum ether

Vorschrift

A quantity of 0.2 gm of 2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine is heated in a bomb tube to 100° C. for three hours with 5 ml of concentrated hydrochloric acid. The reaction mixture is poured onto about 20 ml of ice, neutralized, and extracted with ethyl acetate. After washing with water and drying with magnesium sulfate, the ethyl acetate phase is evaporated. The residue is crystallized by trituration in ether/petroleum ether.

Quelle