Reaktion #3946

Reaktionsgleichung

2-(2-methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

hydrogen peroxide

hydrogen peroxide

→

2-(2-Methoxy-4-methylsulfonyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITfor two hours at 40°-50° C.
2. 2
   Temperaturthe mixture is heated for another hour
3. 3
   SonstigeThe product precipitated
4. 4
   Filtrationis subjected to suction filtration
5. 5
   Waschenwashed with ether

Vorschrift

A quantity of 0.07 gm of 2-(2-methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is dissolved in 5 ml of glacial acetic acid, mixed with 0.05 ml of 30% hydrogen peroxide, and stirred first for 55 minutes at ambient temperature then for two hours at 40°-50° C., Then, a further 0.05 ml of hydrogen peroxide are added, and the mixture is heated for another hour. The product precipitated is subjected to suction filtration and washed with ether.

Quelle