Reaktion #3939

ord-ed77c6d5e9bf4296bf37b6996aa0f6d8

Reaktionsgleichung

CCCCCCN=C=O
n-hexyl isocyanate
Cl.Cl.SCCCN1CCN(CC=Cc2ccccc2)CC1
3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride
CCN(CC)CC
triethylamine
CCCCCCNC(O)=[SH]CCCN1CCN(CC=Cc2ccccc2)CC1.Cl.Cl
N-(n-hexyl)-S-[3-(4-cinnamylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride
Ausbeute 64.2%

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The procedure described in Example 2 was followed, using 0.4 g of n-hexyl isocyanate, 1.0 g of 3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride, 0.6 g of triethylamine and 50 ml of methylene chloride, to give 0.44 g (31% of theory) of N-(n-hexyl)-S-[3-(4-cinnamylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride as a white crystalline solid, M.p. 251°-253° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04722926uspto-grants-1988_02