Reaktion #3933

ord-b3cce434c6ef4afc85c9dbb95a837744

Reaktionsgleichung

CCCCCCN=C=O
n-hexyl isocyanate
SCCCN1CCN(Cc2ccc(Cl)cc2)CC1
3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol
CCCCCCNC(O)=[SH]CCCN1CCN(Cc2ccc(Cl)cc2)CC1.Cl.Cl
N-(n-hexyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride
Ausbeute 157.9%

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The procedure described in Example 35 was followed, using 1.4 g of n-hexyl isocyanate, 3.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol and 100 ml of methylene chloride, to give 2.7 g (51% of theory) of N-(n-hexyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 249°-252° C. (dec.).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04722926uspto-grants-1988_02