Reaktion #3932

ord-0346a80a37094debaa473c96709fc5a5

Reaktionsgleichung

COc1ccc(N=C=O)cc1
4-methoxyphenyl isocyanate
SCCCN1CCN(CCCc2ccc(Cl)cc2)CC1
3-{4-[3-(4-chlorophenyl)propyl]piperazin-1-yl}propanethiol
→
COc1ccc(NC(O)=[SH]CCCN2CCN(CCCc3ccc(Cl)cc3)CC2)cc1.COc1ccc(NC(O)=[SH]CCCN2CCN(CCCc3ccc(Cl)cc3)CC2)cc1.Cl.Cl.Cl.Cl.O
N-(4-methoxyphenyl)-S-{3-[4-[3-(4-chlorophenyl)propyl]piperazin-1-yl]propyl}thiocarbamate dihydrochloride hemihydrate
Ausbeute 146.1%

Edukte

COc1ccc(N=C=O)cc1
4-methoxyphenyl isocyanate
SCCCN1CCN(CCCc2ccc(Cl)cc2)CC1
3-{4-[3-(4-chlorophenyl)propyl]piperazin-1-yl}propanethiol

Reagenzien

Keine

Lösungsmittel

[CH2]Cl
methylene chlorine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The procedure described in Example 35 was followed, using 2.0 g of 4-methoxyphenyl isocyanate, 4.0 g of 3-{4-[3-(4-chlorophenyl)propyl]piperazin-1-yl}propanethiol and 100 ml of methylene chlorine to give 3.4 g (48% of theory) of N-(4-methoxyphenyl)-S-{3-[4-[3-(4-chlorophenyl)propyl]piperazin-1-yl]propyl}thiocarbamate dihydrochloride hemihydrate as a white crystalline solid, M.p. 240°-244° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04722926uspto-grants-1988_02