Reaktion #3931

ord-a34cebc025d14918a8b53e7fb7577a4a

Reaktionsgleichung

O=C=NC1CCCCC1
cyclohexyl isocyanate
SCCCN1CCN(CCc2ccc(Cl)cc2)CC1
3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol
Cl.Cl.OC(NC1CCCCC1)=[SH]CCCN1CCN(CCc2ccc(Cl)cc2)CC1
N-cyclohexyl-S-{3-[4-(4-chlorophenethyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride
Ausbeute 170.7%

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The procedure described in Example 35 was followed, using 1.7 g of cyclohexyl isocyanate, 4.0 g of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol and 100 ml of methylene chloride, to give 3.8 g (58% of theory) of N-cyclohexyl-S-{3-[4-(4-chlorophenethyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 262°-267° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04722926uspto-grants-1988_02