Reaktion #3929

Reaktionsgleichung

thiourea

sodium hydroxide

triethylamine

1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride

→

2-[4-(4-chlorobenzyl)piperazin-1-yl]ethanethiol dihydrochloride

Ausbeute 97.8%

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Vorschrift

The procedure described in Example 1(b) was followed, using 6.1 g of thiourea, 13.8 g of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride, 4.1 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 7.0 g of sodium hydroxide and 50 ml of water. Work-up, as described above, gave 6.7 g (62% of theory) of 2-[4-(4-chlorobenzyl)piperazin-1-yl]ethanethiol dihydrochloride as a white crystalline solid, M.p. 244°-247° C.

Quelle