Reaktion #3914

Reaktionsgleichung

1-(4-chlorophenethyl)piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

Ausbeute 118.3%

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Vorschrift

The procedure described in Example 17(a) was followed, using 6.5 g of 1-(4-chlorophenethyl)piperazine, 6.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 4.6 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 6.4 g (59% of theory) of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Quelle