Reaktion #3909

Reaktionsgleichung

thiourea

sodium hydroxide

triethylamine

1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(1-phenylethyl)piperazin-1-yl]propanethiol dihydrochloride

Ausbeute 51.0%

Lösungsmittel

water

ethanol

Reaktionsbedingungen

Vorschrift

The procedure described in Example 1(b) was followed, using 9.8 g of thiourea, 29.0 g of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 8.3 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as above, gave 14.5 g (51% of theory) of 3-[4-(1-phenylethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 252°-255° C.

Quelle