Reaktion #3893

Reaktionsgleichung

phenyl isocyanate

3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

triethylamine

→

N-phenyl-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride

Ausbeute 107.1%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The procedure described in Example 2 was followed, using 4.3 g of phenyl isocyanate, 12.7 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 7.3 g of triethylamine and 100 ml of methylene chloride, to give 9.1 g (53% of theory) of N-phenyl-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. >230° C. (dec.).

Quelle