Reaktion #3885

Reaktionsgleichung

1-bromo-3-chloropropane

1-benzylpiperazine

dimethyl sulfoxide

potassium hydroxide

→

1-benzyl-4-(3-chloropropyl)piperazine dihydrochloride

Ausbeute 163.9%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe reaction product was extracted with ether
2. 2
   Trocknendried (magnesium sulfate)
3. 3
   Sonstigethe salt was precipitated with ethereal hydrochloric acid

Vorschrift

31.5 g of 1-bromo-3-chloropropane were added to a mixture of 35 g of 1-benzylpiperazine, 150 ml of dimethyl sulfoxide and 25 g of potassium hydroxide. The resulting mixture was stirred at room temperature for 3 hours. Water was added to the resulting solution, the reaction product was extracted with ether, dried (magnesium sulfate), and the salt was precipitated with ethereal hydrochloric acid to give 35.6 g (55% of theory) of 1-benzyl-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Quelle