Reaktion #3872

Reaktionsgleichung

potassium hydroxide

7-hydroxy-3-piperidino-2,2-dimethylbenzofuran

1,4-dibromobutane

→

desired product

7-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Extraktionextracted with 5% aq. HCl
3. 3
   Waschenthe acidic phase washed with ether
4. 4
   SonstigeThe acidic phase is made basic thereby forming an oil which
5. 5
   Waschenwashed with sat'd aq. NaCl
6. 6
   Sonstigedried
7. 7
   Filtrationfiltered
8. 8
   Sonstigeevaporated in vacuo

Vorschrift

Crushed potassium hydroxide (19.6 g) and tetrabutyl ammonium chloride (1.7 g) are added to a solution of 7-hydroxy-3-piperidino-2,2-dimethylbenzofuran (14.4 g) in 1,4-dibromobutane (69.4 ml) and the mixture stirred at RT under nitrogen for 5 hours. The reaction mixture is diluted with ether, washed with water, extracted with 5% aq. HCl and the acidic phase washed with ether. The acidic phase is made basic thereby forming an oil which is taken up in ether, washed with sat'd aq. NaCl, dried, filtered and evaporated in vacuo affording the desired product as a liquid.

Quelle