Reaktion #3864

Reaktionsgleichung

potassium hydroxide

product

6-Hydroxy-4-piperidino-2,3-dihydrobenzopyran

1,3-dibromopropane

→

desired product

6-(3-Bromopropoxy)-4-piperidino-2,3-dihydrobenzopyran

Lösungsmittel

ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Extraktionextracted into 5% aq. HCl
3. 3
   WaschenThe aqueous solution is washed with ether
4. 4
   Sonstigeyielding a yellow oil which
5. 5
   Waschenwashed
6. 6
   Sonstigedried
7. 7
   Filtrationfiltered
8. 8
   Sonstigeevaporated

Vorschrift

Crushed potassium hydroxide (1.15 g) and tetrabutyl ammonium chloride (0.61 g) are added to a solution of the product obtained in Step 3. (4.8 g) in 1,3-dibromopropane (21 ml). The reaction mixture is stirred under nitrogen at RT for 48 hours, diluted with diethyl ether, washed with water and extracted into 5% aq. HCl. The aqueous solution is washed with ether and made alkaline yielding a yellow oil which is taken up in ether, washed, dried, filtered and evaporated to give the desired product as an oil.

Quelle