Reaktion #3860

Reaktionsgleichung

carbonate

potassium carbonate

1,4-dioxane

(Z,Z)-11,13-hexadecadienal

→

(Z,Z)-1,12,14-heptadecatriene

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas prepared in a 100 ml round bottomed flask
2. 2
   Sonstigeequipped with a magnetic stirrer
3. 3
   Temperaturthermometer and reflux condenser
4. 4
   TemperaturThe mixture was heated
5. 5
   Temperaturto reflux at 105°-110°
6. 6
   Sonstigewere withdrawn periodically
7. 7
   Sonstigepartitioned between 1 ml of H2O and 1 ml of hexane
8. 8
   Sonstigeat 1.1 and 2.2 and 17 hr
9. 9
   workup.ADDITIONMore potassium carbonate (1.7 g) was added at 212 hr
10. 10
    Sonstigethe reaction to completion
11. 11
    TemperaturThe reaction mixture was cooled
12. 12
    Extraktionextracted 3 times with 25 ml of hexane
13. 13
    Extraktionthe organic layer was extracted with water
14. 14
    Sonstigedried
15. 15
    Sonstigethe solvent removed

Vorschrift

(Z,Z)-1,12,14-heptadecatriene (TRIENE) was synthesized conveniently from Wittig Salt and aldehyde in aqueous dioxidepotassium carbonate heterogeneous medium (Lechat 1982). A mixture of 3.57 g (0.01 mol) of methyl triphenylphosphonium bromide (Alfa Inorganics), 1.7 g (0.14 mol) of potassium carbonate, 10 ml of 1,4-dioxane, 0.15 ml of water and 2.36 g (0.01 mol) of (Z,Z)-11,13-hexadecadienal (AL. Albany International) was prepared in a 100 ml round bottomed flask equipped with a magnetic stirrer, thermometer and reflux condenser. The mixture was heated to reflux at 105°-110° with stirring while aliquots of 15 ul were withdrawn periodically and partitioned between 1 ml of H2O and 1 ml of hexane. Analysis by gas-liquid chromatography, showed 66, 70 and 99% triolefin and 30%, 26% and 1% starting aldehyde at 1.1 and 2.2 and 17 hr, respectively. More potassium carbonate (1.7 g) was added at 212 hr to drive the reaction to completion. The reaction mixture was cooled and extracted 3 times with 25 ml of hexane, then the organic layer was extracted with water, dried and the solvent removed to leave 1.8 g of yellow oil and a few crystals of triphenylphosphine oxide. The oil was taken up in hexane and passed through a 1×45 cm column of silica gel (60-200 mesh, Baker) with hexane, to yield 1.7 g (73% yield) of clear oil.

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