Reaktion #3804

Reaktionsgleichung

(2-{2-[(tert-butoxycarbonyl-phenyl-methyl)-carbamoyl]-phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid tert-butyl ester

(2-{2-[(tert-Butoxycarbonyl-phenyl-methyl)carbamoyl]-phenyldisulfanyl}-benzoylamino)phenyl-acetic acid tert-butyl ester

dichloromethane

trifluoroacetic acid

→

title compound

Ausbeute 42.5%

(2-{2-[(Carboxy-phenyl-methyl)-carbamoyl]phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid

Ausbeute 42.5%

Lösungsmittel

ether hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared
2. 2
   Filtrationfiltered

Vorschrift

This compound was prepared according to the procedure described in Example 50 using [R-(R*,R*)] (2-{2-[(tert-butoxycarbonyl-phenyl-methyl)-carbamoyl]-phenyldisulfanyl}-benzoylamino)-phenyl-acetic acid tert-butyl ester (0.2 g, 0.3 mmol) from Example 38, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The crude product was stirred with ether/hexane and filtered to afford 73.0 mg of the title compound, mp 231°-232° C.

Quelle