Reaktion #3797

Reaktionsgleichung

2-[2-[2-(1-tert-butoxycarbonyl-3-methyl- butylcarbamoyl)-4-methoxy-phenyldisulfanyl]-5-methoxybenzoylamino]-4-methyl-pentanoic acid tert-butyl ester

2-[2-[2-(1-tert-Butoxycarbonyl-3-methylbutylcarbamoyl)-4-methoxy- phenyldisulfanyl]-5-methoxybenzoylamino]-4-methyl-pentanoic acid tert-butyl ester

trifluoroacetic acid

anisole

→

title compound

Ausbeute 34.7%

2-{2-[2-(1-Carboxy-3-methyl-butylcarbamoyl)-4-methoxy-phenyldisulfanyl]-5-methoxybenzoylamino}-4-methyl-pentanoic acid

Ausbeute 34.7%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared
2. 2
   SonstigeThe crude product was recrystallized from methanol/water

Vorschrift

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)]-2-[2-[2-(1-tert-butoxycarbonyl-3-methyl- butylcarbamoyl)-4-methoxy-phenyldisulfanyl]-5-methoxybenzoylamino]-4-methyl-pentanoic acid tert-butyl ester (2.4 g, 3.4 mmol) from Example 31, 25 mL dichloromethane, 25 mL trifluoroacetic acid and 2.5 mL anisole. The crude product was recrystallized from methanol/water to afford 0.7 g of the title compound, mp 168°-169° C.

Quelle