Reaktion #3750

ord-9c11192e28cf449f8f4481cc2630305b

Reaktionsgleichung

Cl
hydrochloric acid
CCCn1c(N)cc(=O)n(CCC)c1=O
1,3-Di-n-propyl-6-aminouracil
CC(=O)O
acetic acid
O=N[O-].[Na+]
Sodium nitrite
→
CCCn1c(N)c(N=O)c(=O)n(CCC)c1=O
1,3-di-n-propyl-5-nitroso-6-aminouracil
Ausbeute 146.3%

Edukte

Cl
hydrochloric acid
CCCn1c(N)cc(=O)n(CCC)c1=O
1,3-Di-n-propyl-6-aminouracil
CC(=O)O
acetic acid
O=N[O-].[Na+]
Sodium nitrite

Reagenzien

Keine

Lösungsmittel

O
water
O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeA purple precipitate formed
  2. 2
    workup.ADDITIONAddition
  3. 3
    workup.STIRRINGto stir for 2 hours
  4. 4
    FiltrationThe solution was then filtered
  5. 5
    Waschenthe filtrate was rinsed with water
  6. 6
    Sonstigedried under vacuum

Vorschrift

1,3-Di-n-propyl-6-aminouracil (30 g) was suspended in 1 L of water with 41 ml of 20% acetic acid and overhead stirring. Sodium nitrite (9.03 g) in 41 ml of water was added in portions, keeping the solution acidic with 12 ml of concentrated hydrochloric acid. A purple precipitate formed. Addition was complete in 10 minutes and the suspension was allowed to stir for 2 hours. The solution was then filtered, and the filtrate was rinsed with water and dried under vacuum to yield 46 g of 1,3-di-n-propyl-5-nitroso-6-aminouracil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05734052uspto-grants-1998_03