Reaktion #3732

ord-6c0da7e20dd64167a0eceb9e22ecda3c

Reaktionsgleichung

O=c1c2[nH]c([N+](=O)[O-])nc2n(C2CCCCC2)c(=O)n1C1CCCCC1
1,3-di-cyclohexyl-8-nitro xanthine
O=P(Cl)(Cl)Cl
phosphorous oxychloride
→
O=c1c2[nH]c(Cl)nc2n(C2CCCCC2)c(=O)n1C1CCCCC1
1,3-Di-cyclohexyl-8-chloro xanthine

Edukte

O=c1c2[nH]c([N+](=O)[O-])nc2n(C2CCCCC2)c(=O)n1C1CCCCC1
1,3-di-cyclohexyl-8-nitro xanthine
O=P(Cl)(Cl)Cl
phosphorous oxychloride

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was obtained as a crystalline product
  2. 2
    Sonstigeafter recrystallisation from ethyl acetate, m.pt
  3. 3
    Sonstige135° C.

Vorschrift

1,3-Di-cyclohexyl-8-chloro xanthine was prepared from 1,3-di-cyclohexyl-8-nitro xanthine (2 g, 0.006 mol) and phosphorous oxychloride (3.9 g) in dimethylformamide (6 ml), using an analogous procedure to that described in Example 17. The product was obtained as a crystalline product after recrystallisation from ethyl acetate, m.pt., 135° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05734051uspto-grants-1998_03