Reaktion #3726

Reaktionsgleichung

1,3-Di-n-butyl-8-nitro xanthine

1,3-Di-n-butyl-8-nitro Xanthine

tin

hydrochloric acid

→

1,3-Di-n-butyl-8-amino Xanthine Hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThereafter the precipitate was filtered off
2. 2
   Sonstigerecrystallised twice from ethanol
3. 3
   SonstigeThe product formed colourless crystals, yield 5.5 g (63%) m.pt >250° C.

Vorschrift

1,3-Di-n-butyl-8-nitro xanthine from Example 1 (8.5 g) was suspended in concentrated hydrochloric acid (85 ml) and then treated at room temperature with tin powder (14.5 g) in small portions. After stirring for 10 minutes the yellow colour of the suspension disappeared. Thereafter the precipitate was filtered off and recrystallised twice from ethanol. The product formed colourless crystals, yield 5.5 g (63%) m.pt >250° C.

Quelle