Reaktion #3707

Reaktionsgleichung

methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate

NaOH

citric acid

→

desired product

Ausbeute 96.7%

4-[2-(2-Chlorophenyl)-2-oxoethyl]benzoic acid

Ausbeute 96.7%

Lösungsmittel

CH3OH

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 3 hours
2. 2
   SonstigeThe reaction mixture is evaporated in vacuo
3. 3
   Sonstigeto remove the CH3OH
4. 4
   ExtraktionThe aqueous phase is extracted with CH2Cl2
5. 5
   SonstigeThe resulting solid is collected
6. 6
   Sonstigedried under vacuum

Vorschrift

A mixture of 18.78 g of methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate in 288.8 ml of CH3OH, 72.2 ml of water and 5.2 g of NaOH is refluxed for 3 hours then acidified with 2N citric acid. The reaction mixture is evaporated in vacuo to remove the CH3OH. The aqueous phase is extracted with CH2Cl2 and acidified with 1N HCl. The resulting solid is collected and dried under vacuum to give 17.27 g of the desired product, m.p. 168°-172° C.

Quelle