Reaktion #367667

Reaktionsgleichung

6-methoxy-5-trifluoromethyl-1-cyanonaphthalene

potassium hydroxide

methanol

→

6-methoxy-5-trifluoromethyl-1-naphthoic acid

Ausbeute 100.0%

Lösungsmittel

—

20/5

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas charged into an autoclave
2. 2
   TemperaturThe reaction mixture was then cooled
3. 3
   Sonstigeto provide a 98%

Vorschrift

A solution of 0.5 g of 6-methoxy-5-trifluoromethyl-1-cyanonaphthalene and 0.6 g of potassium hydroxide in 25 ml of a 20/5 mixture of methanol and water was charged into an autoclave, heated to 130° C. and stirred for 5-6 hours at an internal pressure of 90-100 psi. The reaction mixture was then cooled and worked up to provide a 98% recovered yield of 100% pure 6-methoxy-5-trifluoromethyl-1-naphthoic acid.

Quelle