Reaktion #367466

Reaktionsgleichung

2,5,7-tribromo-3,4-dihydro-1(2H)-naphthalenone

imidazole

→

2-(1-imidazolyl)-3,4-dihydro-5,7-dibromo-1(2H)-naphthalenone

Ausbeute 62.1%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated under reduced pressure
2. 2
   Waschenwashed with H2O
3. 3
   Extraktionwas extracted with a solution of 8% HCl
4. 4
   Extraktionextracted with CH2Cl2
5. 5
   Sonstigedried
6. 6
   Sonstigeevaporated

Vorschrift

A solution of 2,5,7-tribromo-3,4-dihydro-1(2H)-naphthalenone (1 g), imidazole (0.7 g), and N,N-dimethylformamide (15 ml) was stirred at room temperature for 5 hours. The solvent was evaporated under reduced pressure and the residue, taken up with CH2Cl2 (20 ml), washed with H2O, was extracted with a solution of 8% HCl. The acid solution, neutralized with NaHCO3, extracted with CH2Cl2, dried and evaporated, gave 0.6 g of 2-(1-imidazolyl)-3,4-dihydro-5,7-dibromo-1(2H)-naphthalenone;

Quelle