Reaktion #367435

Reaktionsgleichung

6-chloro-2[(4-methoxyphenyl)amino]-3-nitrobenzoic acid

phosphorus oxychloride

→

title compound

1,9-Dichloro-7-methoxy-4-nitroacridine

Lösungsmittel

chlorobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   Temperaturto reflux temperature over a period of one hour
3. 3
   Temperaturunder reflux for 4.5 hours
4. 4
   Temperaturto cool
5. 5
   Sonstigethe precipitate collected

Vorschrift

A stirred mixture of 12.9 of 6-chloro-2[(4-methoxyphenyl)amino]-3-nitrobenzoic acid, 25 ml of chlorobenzene and 50 ml of phosphorus oxychloride is heated to reflux temperature over a period of one hour, and held under reflux for 4.5 hours. The mixture is allowed to cool, the precipitate collected, providing the yellow title compound, mp 243-246 degrees after recrystallization from toluene.

Quelle