Reaktion #367219
ord-91459bcd657c4ad9b89aeb1ee04995d5
Reaktionsgleichung
3,5-diiodosalicylic acid
1-(4-amino-2-chloro-6-methylphenyl)-1-(4-chlorophenyl)ethylene
phosphorus trichloride
→
N-[3-chloro-5-methyl-4-[1-(4-chlorophenyl)ethenyl]phenyl]-3,5-diiodo-2-hydroxybenzamide
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
Using the reaction sequence of Example 4, 3,5-diiodosalicylic acid is reacted with 1-(4-amino-2-chloro-6-methylphenyl)-1-(4-chlorophenyl)ethylene in the presence of phosphorus trichloride to give N-[3-chloro-5-methyl-4-[1-(4-chlorophenyl)ethenyl]phenyl]-3,5-diiodo-2-hydroxybenzamide. The benzophenone used as starting material for the Wittig reaction was prepared by reacting 4-chlorobenzyl cyanide with 3-chloro-5-methyl-1-nitrobenzene followed by oxidation with alkaline peroxide as known in the literature.