Reaktion #366938

Reaktionsgleichung

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

Ausbeute 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

Ausbeute 92.8%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   Temperaturchilled
4. 4
   Filtrationfiltered
5. 5
   Sonstigedried

Vorschrift

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

Quelle