Reaktion #366794

Reaktionsgleichung

methyl 2-methyl-pyridine-4-carboxylate

lithium aluminium hydride

Water

→

4-hydroxymethyl-2-methylpyridine

Ausbeute 38.0%

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe mixture was filtered through diatomaceous earth
2. 2
   Waschenthe pad was washed through with ethyl acetate
3. 3
   ExtraktionThe filtrate was extracted with ethyl acetate
4. 4
   Waschenthe combined extracts were washed with brine
5. 5
   Trocknendried (MgSO4)
6. 6
   Sonstigethe solvent removed by evaporation

Vorschrift

A solution of methyl 2-methyl-pyridine-4-carboxylate (800 mg, 6 mmol) in ether (5 ml) was added to lithium aluminium hydride (340 mg, 9mmol) in ether (10 ml) cooled to 5° C. and the mixture stirred for 2 hours. Water was added, the mixture was filtered through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was extracted with ethyl acetate and the combined extracts were washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-hydroxymethyl-2-methylpyridine (240 mg, 38%) as a yellow oil.

Quelle