Reaktion #3667

Reaktionsgleichung

Water

N,N-diisopropylethylamine

2,4-dichlorobenzylchloride

2-chloro-4-aminobenzoic acid

→

desired product

4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer dried with Na2 SO4
2. 2
   Einengenconcentrate in vacuo

Vorschrift

To a stirred mixture of 5.19 g of 2-chloro-4-aminobenzoic acid in 150 ml of methylene chloride is added 7.86 g of N,N-diisopropylethylamine and 12.67 g of 2,4-dichlorobenzylchloride and stirring continued for 18 hours. Water is added to the filtrate and the organic layer dried with Na2 SO4 and concentrate in vacuo to give 13.68 g of the desired product, m.p. 171°-175° C.

Quelle