Reaktion #366216

Reaktionsgleichung

9H,10H-5,8,11-trioxabenzo[de]anthracene-4,6-dione

hydroxylamine hydrochloride

water

→

title compound

Ausbeute 97.0%

5-Hydroxy-9H,10H-8,11-dioxa-5-aza-benzo[de]anthracene-4,6-dione

Ausbeute 97.0%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture refluxed for 1.5 hours
2. 2
   SonstigeThe precipitate was isolated after 24 hours
3. 3
   Waschenwashed with water, 1% HCl, water
4. 4
   Sonstigedried

Vorschrift

To a solution of 70 mg (0.27 mmol) of 9H,10H-5,8,11-trioxabenzo[de]anthracene-4,6-dione (from Example R3) in 4 mL pyridine was added 80 mg (1.16 mmol) of hydroxylamine hydrochloride and the reaction mixture refluxed for 1.5 hours and poured into 20 mL water while hot. The precipitate was isolated after 24 hours, washed with water, 1% HCl, water, and dried to yield 71 mg of the title compound, mp 344-347° C.

Quelle