Reaktion #3662

Reaktionsgleichung

2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione

N-formylhydrazine

→

gray solid

Ausbeute 37.3%

4,5-Dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine

Ausbeute 37.3%

Lösungsmittel

n-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 18 hours
2. 2
   Sonstigethe solvent removed under vacuum
3. 3
   workup.ADDITIONIce water is added to the residual solid
4. 4
   Filtrationthe mixture filtered

Vorschrift

A mixture of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione (0.8 g) and 0.80 g of N-formylhydrazine in 8 ml of n-butanol is stirred and refluxed for 18 hours and the solvent removed under vacuum. Ice water is added to the residual solid and the mixture filtered to give 0.312 g of a gray solid, m.p. 162°-165° C.

Quelle