Reaktion #365644

Reaktionsgleichung

2-Hydroxyoctanoic acid

hydrogen chloride methanol

→

methyl 2-hydroxyoctanoate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction mixture was evaporated under reduced pressure
2. 2
   SonstigeThe residue was partitioned between ethyl acetate and water
3. 3
   WaschenThe organic layer was washed with aqueous NaHCO3 solution
4. 4
   Trocknendried over sodium sulfate
5. 5
   SonstigeEvaporation of the solvent under reduced pressure

Vorschrift

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

Quelle