Reaktion #365508

Reaktionsgleichung

3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-piperidinecarboxylic acid

3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-N-hydroxy-3-piperidinecarboxamide hydrogen chloride

→

3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-N-hydroxy-3-piperidinecarboxamide

Ausbeute 43.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas isolated as a white solid

Vorschrift

Starting from 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-piperidinecarboxylic acid (1.1 g, 2.4 mmol) and and following the procedure as outlined in example 1, (step 8), 0.48 g of 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-N-hydroxy-3-piperidinecarboxamide hydrogen chloride was isolated as a white solid. Yield 43%; mp 124.4° C.; MS (ES): m/z: 477.1 (M+H)+; 1H NMR (300 MHz, DMSO-d6): δ2.0 (m, 2H), 3.39 (m, 5H), 4.27 (d, 2H), 4.89 (m, 2H), 7.14 (d, 2H), 7.15 (m, 4H), 7,61 (d, 2H), 8.95 (s, 1H), 9.46 (s, 1H).

Quelle