Reaktion #365167

Reaktionsgleichung

2-amino-5-nitro-6-methylpyridine

sulfuric acid

sodium nitrate

→

title compound

Ausbeute 97.0%

2-Oxo-5-Nitro-6-Methyl-1,2-Dihydropyridine

Ausbeute 97.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe reaction mixture was warmed to room temperature over 4 hours
3. 3
   Temperaturcooled to 0° C
4. 4
   SonstigeThe resulting ivory precipitate was collected
5. 5
   Waschenwashed with cold water
6. 6
   Sonstigedried at 40° C. in vacuo overnight

Vorschrift

To a suspension of 2-amino-5-nitro-6-methylpyridine (40.24 g, 260 mmol) was added concentrated sulfuric acid (48 mL). The homogeneous solution was cooled to 0° C., and sodium nitrate (26.97 g, 390 mmol) dissolved in 120 mL of water was added. The reaction mixture was warmed to room temperature over 4 hours, then cooled to 0° C. The resulting ivory precipitate was collected, washed with cold water, and dried at 40° C. in vacuo overnight to provide 39.05 g (97%) of the title compound. EA calculated for C6H6N2O3: C, 46.76; H, 3.92; N, 18.18. Found: C, 46.49; H, 3.94; N, 17.99.

Quelle