Reaktion #364997

ord-afd9143a1270495c8261ccc49d45304e

Reaktionsgleichung

CC(=O)NC[C@H]1CN(c2ccc(C3CCNCC3)cc2)C(=O)O1
(S)-(−)-N-[[2-oxo-3-[4-(4-piperidinyl)phenyl]-5-oxazolidinyl]methyl]acetamide
CC(=O)OCC(=O)Cl
acetoxyacetyl chloride
O=C(Cl)COCc1ccccc1
benzyloxyacetyl chloride
→
CC(=O)NC[C@H]1CN(c2ccc(C3=CCN(C(=O)COC(C)=O)CC3)cc2)C(=O)O1
title compound
CC(=O)NC[C@H]1CN(c2ccc(C3=CCN(C(=O)COC(C)=O)CC3)cc2)C(=O)O1
(S)-(−)-N-[[2-Oxo-3-[4-[1-[(acetoxy)acetyl]-3,6-dihydro-2H-pyridin-4-yl]phenyl]-5-oxazolidinyl]methyl]acetamide

Edukte

CC(=O)NC[C@H]1CN(c2ccc(C3CCNCC3)cc2)C(=O)O1
(S)-(−)-N-[[2-oxo-3-[4-(4-piperidinyl)phenyl]-5-oxazolidinyl]methyl]acetamide
CC(=O)OCC(=O)Cl
acetoxyacetyl chloride
O=C(Cl)COCc1ccccc1
benzyloxyacetyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the general procedure of EXAMPLE 18, and making non-critical variations but substituting (S)-(−)-N-[[2-oxo-3-[4-(3,6-dihydro-2H-pyridin-4-yl)phenyl]-5-oxazolidinyl]methyl]acetamide (EXAMPLE 58) for (S)-(−)-N-[[2-oxo-3-[4-(4-piperidinyl)phenyl]-5-oxazolidinyl]methyl]acetamide and acetoxyacetyl chloride for benzyloxyacetyl chloride, the title compound is obtained, HRMS calcd for C21H25N3O6: 415.1743. Found: 415.1752.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06358942B1uspto-grants-2002_03