Reaktion #364897

Reaktionsgleichung

2-phenylimidazole

→

2-cyclohexylimidazole

Lösungsmittel

hydrochloric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthen filtered through celite
2. 2
   Extraktionextracted with 2×100 mL ethyl acetate
3. 3
   ExtraktionThe combined extract
4. 4
   Waschenwas washed with 200 mL of brine
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   SonstigeEvaporation of the solvent

Vorschrift

To a solution of 6.8 g of 2-phenylimidazole in 200 mL 3N hydrochloric acid was added 5% Rhodium on Carbon, Degussa type G10 NB/W. The mixture was hydrogenated at 100 psi for 24 hours then filtered through celite. The solution was neutralized with 25% sodium hydroxide and extracted with 2×100 mL ethyl acetate. The combined extract was washed with 200 mL of brine and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 2-cyclohexylimidazole as a fluffy, white solid which was used in the next step without further purification or characterization.

Quelle