Reaktion #364656

Reaktionsgleichung

ethyl 2-chloro-1-[(2′-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate

NaOEt

→

title compound

Ausbeute 70.0%

Ethyl 1-[(2′-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

Ausbeute 70.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturunder reflux for 1 hour
3. 3
   EinengenThe reaction mixture was concentrated to dryness
4. 4
   workup.DISSOLUTIONThe resultant residue was dissolved in ethyl acetate
5. 5
   Waschenthe solution was washed with water
6. 6
   Sonstigedried
7. 7
   SonstigeAfter evaporation of the solvent
8. 8
   Sonstigethe residue was purified by column chromatography on silica gel

Vorschrift

To a solution of ethyl 2-chloro-1-[(2′-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (1.0 g) in ethanol (30 ml) was added NaOEt (0.17 g) and the mixture was heated under reflux for 1 hour. The reaction mixture was concentrated to dryness. The resultant residue was dissolved in ethyl acetate and the solution was washed with water, and then dried. After evaporation of the solvent, the residue was purified by column chromatography on silica gel to give the title compound as colorless crystals(0.37 g, 70%). 1H-NMR and IR spectra indicate that the product according to this working Example is completely identical with that obtained in Working Example 4.

Quelle