Reaktion #364089

Reaktionsgleichung

sodium hydride

1-Methyl-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H) -one

diisopropyl ether

1,4-dibromobutane

→

title compound

Ausbeute 75.0%

2a-(4-Bromobutyl)-l-methyl-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Ausbeute 75.0%

Lösungsmittel

N,N-dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction solution was cooled in an ice bath of −10° C.
2. 2
   Sonstige1 hour of the reaction
3. 3
   Temperaturwas increased to a room temperature
4. 4
   Extraktionthe reaction product was extracted
5. 5
   WaschenThen the resulting organic layer was washed three times with water
6. 6
   Trocknendried with anhydrous sodium sulfate
7. 7
   SonstigeDiisopropyl ether was evaporated under a reduced pressure
8. 8
   Sonstigethe thus obtained oily residue was separated
9. 9
   Sonstigepurified by a silica gel column chromatography (developing system: diisopropyl ether)

Vorschrift

1-Methyl-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H) -one (3.7 g, 20 mmol) was dissolved in anhydrous N,N-dimethylformamide (50 ml). Thereto was added sodium hydride (60% content, 800 mg, 20 mmol), and the resulting solution was stirred at a room temperature for 30 minutes. The reaction solution was cooled in an ice bath of −10° C., mixed with 1,4-dibromobutane (7.0 ml) and then 1 hour of the reaction was carried out while temperature of the reaction solution was increased to a room temperature. The reaction solution was mixed with diisopropyl ether (150 ml) and water (100 ml), and the reaction product was extracted. Then the resulting organic layer was washed three times with water and dried with anhydrous sodium sulfate. Diisopropyl ether was evaporated under a reduced pressure, and the thus obtained oily residue was separated and purified by a silica gel column chromatography (developing system: diisopropyl ether) to obtain 4.8 g of the title compound (15 mmol, 75% in yield).

Quelle