Reaktion #363763

Reaktionsgleichung

1-Chloromethylcyclopentanamine HCl salt

2,3-dimethyl-6-nitrophenyl isothiocyanate

2,3-dimethyl-6-nitrophenyl isothiocyanate

2,3-dimethyl-6-nitroaniline

aniline

2-hydroxyethylamine

1-chloromethylcyclopentanamine HCl salt

2,3-Dimethylaniline

→

1-Hydroxymethylcyclopentanamine

2-(2,3-dimethyl-6-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane

Reaktionsbedingungen

Vorschrift

2,3-Dimethylaniline was converted to 2,3-dimethyl-6-nitroaniline according to Method A4a. The aniline was converted to 2,3-dimethyl-6-nitrophenyl isothiocyanate according to Method A2d. 1-Hydroxymethylcyclopentanamine was prepared according to Method B1c. The 2-hydroxyethylamine was converted to 1-chloromethylcyclopentanamine HCl salt according to Method B7e. 1-Chloromethylcyclopentanamine HCl salt was reacted with 2,3-dimethyl-6-nitrophenyl isothiocyanate according to Method C1e to give 2-(2,3-dimethyl-6-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2b to afford 2-(2,3-dimethyl-6-nitrophenylimino)-1-isobutyl-3-thia-1-azaspiro[4.4]nonane.

Quelle