Reaktion #363672
ord-e57f662bf6bf414e97d9c41c6fe6e8a0
Reaktionsgleichung
(1R)-1-Isopropyl-2-hydroxyethylamine
SOCl2
2-Methyl-4-nitrophenyl isothiocyanate
→
(4R)-2-(2-methyl-4-nitrophenylimino)-4-isopropyl-1,3-thiazolidine
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
(1R)-1-Isopropyl-2-hydroxyethylamine was reacted with SOCl2 followed by 2-Methyl-4-nitrophenyl isothiocyanate according to Method C2a to give (4R)-2-(2-methyl-4-nitrophenylimino)-4-isopropyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4R)-2-(2-methyl -4-nitrophenylimino)-4-isopropyl-3-isobutyl-1,3-thiazolidine.