Reaktion #363623
ord-9b9b4a47d5024dd186f1bf36b3a6497c
Reaktionsgleichung
(1S)-1-(Hydroxymethyl)-3-methylbutylamine
2-Methyl-4-nitrophenyl isothiocyanate
→
(4S)-2-(2-methyl-4-nitrophenylimino)-4-isobutyl-1,3-thiazolidine
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was converted to (1S)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-4-nitrophenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4S)-2-(2-methyl-4-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with 1-bromo-2-ethylbutane according to Method D2a to afford (4S)-2-(2-methyl-4-nitrophenylimino)-4-isobutyl-3-(2-ethyl-1-butyl)-1,3-thiazolidine HCl salt.