Reaktion #363619
ord-f63cc2a6d4e64a67b313d13df2fa9c98
Reaktionsgleichung
(1S)-1-(Hydroxymethyl)-3-methylbutylamine
2-Methyl-5-nitrophenyl isothiocyanate
→
(4S)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-1,3-thiazolidine
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was converted to (1S)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-5-nitrophenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4S)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(2-methyl-5-nitrophenylimino)-3,4-diisobutyl-1,3-thiazolidine HCl salt.