Reaktion #363613

Reaktionsgleichung

3-Quinoline isothiocyanate

N-(isobutyl)ammonium chloride

3-Aminoquinoline

2-hydroxyethylamine

(1S)-1-(Hydroxymethyl)-3-methylbutylamine

(L)-leucine methyl ester

(2S)-4-methyl-2-(isobutylamino)pentanol

N-(isobutyl)ammonium chloride

3-quinoline isothiocyanate

→

2-(3-quinolylimino)-3,5-diisobutyl-1,3thiazolidine

Reaktionsbedingungen

Vorschrift

3-Aminoquinoline was converted to 3-quinoline isothiocyanate according to Method A2c. (1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentanol as described in Method B4c, Steps 1-2. The alcohol was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride as described in Method B7c. 3-Quinoline isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method C1f to give 2-(3-quinolylimino)-3,5-diisobutyl-1,3thiazolidine.

Quelle